Papers And Originals

Miosis during L-Dopa Therapy

Br Med J 1970; 2 doi: (Published 13 June 1970) Cite this as: Br Med J 1970;2:639
  1. A. S. D. Spiers,
  2. D. B. Calne,
  3. P. M. Fayers


    The pupillary diameter of 11 patients with Parkinson's disease was significantly decreased four hours after ingestion of L-dopa. It is suggested that this miosis may be caused by diminished noradrenaline output at sympathetic nerve endings, or alternatively by an action on the central nervous system.