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Papers And Originals

Glibenclamide Therapy in Diabetes Mellitus

Br Med J 1970; 2 doi: (Published 06 June 1970) Cite this as: Br Med J 1970;2:570
  1. S. K. Bhatia,
  2. D. R. Hadden,
  3. D. A. D. Montgomery,
  4. J. A. Weaver


    In an initial trial of glibenclamide in the treatment of maturity onset diabetes mellitus 28 patients were treated for up to one year and no toxic effects or side-effects were encountered. The hypoglycaemic potency of this drug is such that 5 mg. of glibenclamide corresponds to about 1,500 mg. of tolbutamide and 375 mg. of chlorpropamide.