Papers And Originals

Drug Intoxication and Neurological Episodes in Chronic Renal Failure

Br Med J 1970; 2 doi: (Published 16 May 1970) Cite this as: Br Med J 1970;2:394
  1. G. Richet,
  2. E. Lopez de Novales,
  3. P. Verroust


    Of 178 episodes of neurological derangement in 103 patients with renal failure, only about 40% were due to known causes such as hypertension or electrolyte failure. One-third were due to drug intoxication and no definite aetiology was found for the remainder. Drug intoxication is due partly to the accumulation of a drug normally excreted by the kidney and partly to a greater susceptibility of the central nervous system in uraemic patients. The prognosis is favourable.