Drug Intoxication and Neurological Episodes in Chronic Renal FailureBr Med J 1970; 2 doi: https://doi.org/10.1136/bmj.2.5706.394 (Published 16 May 1970) Cite this as: Br Med J 1970;2:394
- G. Richet,
- E. Lopez de Novales,
- P. Verroust
Of 178 episodes of neurological derangement in 103 patients with renal failure, only about 40% were due to known causes such as hypertension or electrolyte failure. One-third were due to drug intoxication and no definite aetiology was found for the remainder. Drug intoxication is due partly to the accumulation of a drug normally excreted by the kidney and partly to a greater susceptibility of the central nervous system in uraemic patients. The prognosis is favourable.