Papers And Originals

Cardiac Abnormalities in Poisoning with Tricyclic Antidepressants

Br Med J 1969; 2 doi: (Published 07 June 1969) Cite this as: Br Med J 1969;2:610
  1. J. W. Freeman,
  2. G. R. Mundy,
  3. R. R. Beattie,
  4. C. Ryan


    Of 80 consecutive admissions to a general hospital for drug overdose, 10 had taken one or other of the tricyclic antidepressants. All 10 had abnormalities of cardiac conduction as shown by prolonged Q–Te intervals, and eight had S–T segment and T-wave changes. Five of the 10 patients had arrhythmias and two of these died. Continuous electrocardiographic monitoring is recommended in patients with overdosage of tricyclic antidepressants.