Preliminary Communications

Further Study into Obstructive Jaundice and Ischaemic Renal Damage

Br Med J 1969; 2 doi: (Published 26 April 1969) Cite this as: Br Med J 1969;2:229
  1. M. Baum,
  2. G. A. Stirling,
  3. J. L. Dawson


    Renal ischaemia for one hour in two groups of Gunn rats, one with and the other without bile-duct ligation, produced comparable reversible renal tubular lesions in both groups. Since Gunn rats have an unconjugated hyperbilirubinaemia, which is unaffected by bile-duct ligation, it seems likely that the high levels of bilirubin glucuronide are responsible for sensitizing the renal tubules to ischaemia, possibly by depressing cell respiration.

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