Preliminary Communications

Pituitary Polypeptide with Hypoglycaemic Action in Diabetes Mellitus

Br Med J 1969; 2 doi: (Published 19 April 1969) Cite this as: Br Med J 1969;2:157
  1. J. McD. Armstrong,
  2. J. Bornstein,
  3. F. M. Ng,
  4. H. P. Taft


    A polypeptide isolated by the hydrolysis of growth hormone, studied in five patients with diabetes mellitus, has been shown able to produce hypoglycaemia, presumably by modifying the anti-insulin action of pituitary growth hormone. Possibly this substance may be suitable for treating cases of insulin resistance or when a circulating inhibitor of glucose uptake is present.

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