Intended for healthcare professionals

Research Article

Dissociation of absorptions of calcium and phosphate after successful cadaveric renal transplantation.

Br Med J 1979; 1 doi: (Published 17 March 1979) Cite this as: Br Med J 1979;1:712
  1. K Farrington,
  2. Z Varghese,
  3. S P Newman,
  4. K Y Ahmed,
  5. O N Fernando,
  6. J F Moorhead


    Calcium and phosphate absorptions were studied by radiotracer techniques in 30 patients after successful cadaveric renal transplantation, and results were compared with those in a group of normal subjects and in groups of patients with chronic renal failure (CRF). Both calcium and phosphate absorptions were impared in patients with CRF, including those receiving haemodialysis. Abnormalities of calcium absorption, however, seemed to occur earlier in the course of advanced renal failure than abnormalities in phosphate absorption. Calcium absorption improved dramatically after successful renal transplantation, while phosphate absorption remained the same. A dissociation between calcium and phosphate absorptions is not often seen clinically, and the mechanisms for it are unknown. Phosphate malabsorption may be a further contributing factor in the development of persistent hypophosphataemia after transplantation.