Research Article

Metronidazole in prevention and treatment of bacteroides infections in elective colonic surgery.

Br Med J 1977; 1 doi: (Published 05 March 1977) Cite this as: Br Med J 1977;1:607
  1. A T Willis,
  2. I R Ferguson,
  3. P H Jones,
  4. K D Phillips,
  5. P V Tearle,
  6. R V Fiddian,
  7. D F Graham,
  8. D H Harland,
  9. D F Hughes,
  10. D Knight,
  11. W M Mee,
  12. N Pashby,
  13. R L Rothwell-Jackson,
  14. A K Sachdeva,
  15. I Sutch,
  16. C Kilbey,
  17. D Edwards


    A double-blind randomised trial was carried out among 46 patients undergoing elective colonic surgery; 27 patients received prophylactic metronidazole and 19 received placebo. Anaerobic infections did not develop in any of the metronidazole-treated patients, but did develop in 11 (58%) of 19 controls who were subsequently successfully treated with metronidazole.