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Research Article

Successful bone marrow transplant for Fanconi's anaemia.

Br Med J 1977; 1 doi: (Published 12 February 1977) Cite this as: Br Med J 1977;1:420
  1. A J Barrett,
  2. W D Brigden,
  3. J R Hobbs,
  4. K Hugh-Jones,
  5. J G Humble,
  6. D C James,
  7. S Retsas,
  8. T R Rogers,
  9. S Selwyn,
  10. P Sneath,
  11. J G Watson


    A 15-year-old boy with Fanconi's anaemia, who required four units of blood each month, received a bone marrow graft from his 9-year-old brother, who has HLA identical and compatible on mixed lymphocyte reaction. Considerable immunosuppression was used and bacterial infection was prevented by vigorous decontamination in a Vickers-Trexler isolator. After the graft the patient's blood counts remained satisfactory for nine months, but it took six months before qualitative immune function was normal.