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Research Article

Immediate effects of tobramycin on human cochlea and correlation with serum tobramycin levels.

Br Med J 1977; 1 doi: (Published 29 January 1977) Cite this as: Br Med J 1977;1:259
  1. P Wilson,
  2. R T Ramsden


    Electrocochleography was performed on three patients to monitor the intravenous administration of tobramycin. When peak serum tobramycin levels exceeded 8-10 mug/ml an immediate dramatic reduction in cochlear output was observed, which recovered fully as serum levels fell. The patients had no auditory or vestibular symptoms either during or after treatment.