Evidence for familial immune defect in meningococcal meningitis.Br Med J 1976; 1 doi: https://doi.org/10.1136/bmj.1.6020.1247 (Published 22 May 1976) Cite this as: Br Med J 1976;1:1247
- H C Whittle,
- A Oduloju,
- G Evans-Jones,
- B M Greenwood
Twenty-six patients who had recovered from group A meningococcal meningitis were vaccinated with group C meningococcal polysaccharide and tetanus toxoid. Their haemagglutinating antibody response was measured two weeks later and compared with those of 22 siblings and 39 controls. Patients and siblings had a significantly lower antibody response to the group C vaccine but not to tetanus toxoid. This suggests that patients susceptible to meningococcal disease may have an immune defect involving their response to meningococcal polysaccharides.