Intended for healthcare professionals

Research Article

Evidence for familial immune defect in meningococcal meningitis.

Br Med J 1976; 1 doi: (Published 22 May 1976) Cite this as: Br Med J 1976;1:1247
  1. H C Whittle,
  2. A Oduloju,
  3. G Evans-Jones,
  4. B M Greenwood


    Twenty-six patients who had recovered from group A meningococcal meningitis were vaccinated with group C meningococcal polysaccharide and tetanus toxoid. Their haemagglutinating antibody response was measured two weeks later and compared with those of 22 siblings and 39 controls. Patients and siblings had a significantly lower antibody response to the group C vaccine but not to tetanus toxoid. This suggests that patients susceptible to meningococcal disease may have an immune defect involving their response to meningococcal polysaccharides.