Intended for healthcare professionals

Research Article

A controlled comparison of flupenthixol and amitriptyline in depressed outpatients.

Br Med J 1976; 1 doi: (Published 08 May 1976) Cite this as: Br Med J 1976;1:1116

This article has a correction. Please see:

  1. J P Young,
  2. W C Hughes,
  3. M H Lader


    Sixty depressed outpatients were allocated to treatment with either amitriptyline (75-225 mg/day) or flupenthixol (1-5-4-5 mg/day) in flexible dosage for six weeks under double-blind procedures. Various objective and subjective assessments were carried out before and after one, three, and six weeks of treatment. Twenty-three patients completed the course of amitriptyline and 28 the course of flupenthixol. Almost all variables improved significantly over time, irrespective of drug. On most ratings there were no significant differences between the two drugs, but the trends favoured flupenthixol. In particular, flupenthixol lessened anxiety scores more than amitriptyline. Unwanted effects were few and not troublesome except in two patients receiving amitriptyline. Flupenthixol, in low dosage, is a useful alternative antidepressant for depressed outpatients.