Research Article

T lymphocytes in kidney allograft recipients.

Br Med J 1976; 1 doi: (Published 03 April 1976) Cite this as: Br Med J 1976;1:799

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  1. T Tursz,
  2. C Fournier,
  3. H Kreis,
  4. J Crosnier,
  5. J F Bach


    The spontaneous sheep erythrocyte (E) rosette test was used on 340 occasions to measure T cell levels in 28 renal allograft recipients. The E rosette counts were reduced by high-dose steroids but usually returned towards normal under maintenance treatment with azathioprine and low-dose prednisone. Unexpectedly, rejection crises were more often associated with a decrease in E rosettes before steroid treatment (12 cases) than with an increase in E rosettes (5 cases). Our results show the need for caution in using the E rosette test and more generally B and T cell markers for monitoring anti-graft immunity in renal allograft recipients.