Short ACTH test in assessing hypothalamic-pituitary-adrenocortical function.Br Med J 1976; 1 doi: https://doi.org/10.1136/bmj.1.6004.249 (Published 31 January 1976) Cite this as: Br Med J 1976;1:249
- H Kehlet,
- M Blichert-Toft,
- J Lindholm,
- P Rasmussen
The adrenocortical response to the simple 30-minute ACTH stimulation test was compared with the hypothalamic-pituitary-adrenocortical (HPA) response to insulin-induced hypoglycaemia in 25 patients with various degrees of hypothalamic-pituitary malfunction. The correlations between the increase in plasma cortisol during insulin hypoglycaemia and that during ACTH stimulation (r = 0-66) and between peak plasma cortisol levels during the two tests (r = 0-90) were highly significant. Peak plasma cortisol levels in individual patients were similar on both tests, no patient showing any major discrepancy between the two test results. Thus the simple 30-minute ACTH stimulation test seems to be reliable in detecting imparied HPA function.