Research Article

"Topical nephropathy" and "tropical extramembranous glomerulonephritis" of unknown aetiology in Senegal.

Br Med J 1975; 1 doi: (Published 08 March 1975) Cite this as: Br Med J 1975;1:541
  1. L Morel-Maroger,
  2. A G Saimot,
  3. J C Sloper,
  4. D F Woodrow,
  5. C Adam,
  6. I Niang,
  7. M Payet


    A study of renal biopsy specimens obtained in Senegal from 24 children and six adults with nephrotic syndrome showed two unusual varieties of nephropathy--namely, an extramembranous glomerulonephritis associated with hypocomplementaemia (four cases), a combination previously described only in systemic lupus erythematosus, and a "tropical nephropathy" (16 cases). The latter, though lacking the diffuse glomerular deposits of immunoglobulin described in quartan malarial nephropathy (Q.M.N.), showed a curious progressive and segmental glomerulosclerosis, characterized by a "flaking" or fibrillary splitting of the glomerular capillary wall, seen in Q.M.N. Serological evidence of malaria was lacking in a third of the childhood cases.