Papers And Originals

Diurnal Variation in Response to Intravenous Glucose

Br Med J 1974; 1 doi: (Published 16 March 1974) Cite this as: Br Med J 1974;1:488
  1. Margaret J. Whichelow,
  2. R. A. Sturge,
  3. H. Keen,
  4. R. J. Jarrett,
  5. L. Stimmler,
  6. Susan Grainger


    Intravenous glucose tolerance tests (25 g) were performed in the morning and afternoon on 13 apparently normal persons. The individual K values (rate of decline of blood sugar) were all higher in the morning tests, and the mean values were significantly higher in the morning. Fasting blood sugar levels were slightly lower in the afternoon. There was no difference between the fasting morning and afternoon plasma insulin levels, but the levels after glucose were lower in the afternoon. Growth hormone levels were low at all times in non-apprehensive subjects and unaffected by glucose. The results suggest that the impaired afternoon intravenous glucose tolerance, like oral glucose tolerance, is associated with impaired insulin release and insulin resistance.


    • * Paper presented at the 8th Congress of the International Diabetes Federation, Brussels, July 1973.