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Medical Practice

A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial Infarction

Br Med J 1974; 1 doi: (Published 09 March 1974) Cite this as: Br Med J 1974;1:436
  1. P. C. Elwood,
  2. A. L. Cochrane,
  3. M. L. Burr,
  4. P. M. Sweetnam,
  5. G. Williams,
  6. E. Welsby,
  7. S. J. Hughes,
  8. R. Renton


    The results of a randomized controlled trial of a single daily dose of acetyl salicylic acid (aspirin) in the prevention of reinfarction in 1,239 men who had had a recent myocardial infarct were statistically inconclusive. Nevertheless, they showed a reduction in total mortality of 12% at six months and 25% at twelve months after admission to the trial. Further trials are urgently required to establish whether or not this effect is real.