Papers And Originals

Colonic Response to Pentazocine

Br Med J 1974; 1 doi: (Published 23 February 1974) Cite this as: Br Med J 1974;1:312
  1. C. Stanciu,
  2. John R. Bennett


    The effects of pentazocine on colonic motor activity were studied in five normal subjects, five patients with irritable bowel syndrome, and five patients with diverticular disease. The drug decreased intraluminal colonic pressures in all patients but one. Since morphine, which increases intraluminal colonic pressures, is contraindicated in patients with abdominal pain of colonic origin (diverticular disease, irritable bowel syndrome), we suggest that pentazocine may be a useful drug in such cases.