Papers And Originals

Double-blind Trial of Linoleate Supplementation of the Diet in Multiple Sclerosis

Br Med J 1973; 1 doi: (Published 31 March 1973) Cite this as: Br Med J 1973;1:765
  1. J. H. D. Millar,
  2. K. J. Zilkha,
  3. M. J. S. Langman,
  4. H. Payling Wright,
  5. A. D. Smith,
  6. J. Belin,
  7. R. H. S. Thompson


    Seventy-five patients in London and Belfast with multiple sclerosis were given daily supplements of a vegetable oil mixture containing either linoleate or oleate for two years in a double-blind control trial. Relapses tended to be less frequent and were significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.