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Abnormal Excretion of Corticosteroid Sulphates in Patients with Breast Cancer

Br Med J 1973; 1 doi: (Published 10 February 1973) Cite this as: Br Med J 1973;1:328
  1. P. C. Ghosh,
  2. E. Lockwood,
  3. G. W. Pennington


    In a preliminary study, the 24-hour urinary excretion of corticosteroid sulphates and free cortisol have been measured in a group of patients with breast cancer and compared with the excretion of the same compounds in a group of normal women of similar age. Excretion of corticosteroid sulphates in the breast cancer group was found to be markedly raised. In a small number of patients with localized cancer of sites other than the breast the level of corticosteroid sulphate was not raised. If proved metastases were present a noticeable rise was observed.