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Comparative trial of Co-trimoxazole and Chloramphenicol in Typhoid Fever

Br Med J 1973; 1 doi: (Published 13 January 1973) Cite this as: Br Med J 1973;1:82
  1. H. V. Sardesai,
  2. R. S. Karandikar,
  3. R. G. Harshe


    A comparative trial of co-trimoxazole and chloramphenicol was conducted in two groups of 50 patients each to try to resolve conflicting opinions on the relative merits of the two drugs in the treatment of typhoid fever. We conclude that in our part of India co-trimoxazole is superior to chloramphenicol and that differences in our findings to those of others may perhaps be accounted for by differences in strains of Salmonella typhi, ethnic differences, and possibly differences in herd immunity to typhoid.