Papers And Originals

Use of Benzoctamine as Sedative in Patients with Respiratory Failure

Br Med J 1973; 1 doi: (Published 13 January 1973) Cite this as: Br Med J 1973;1:75
  1. T. J. H. Clark,
  2. J. V. Collins


    Benzoctamine (Tacitin) was given by mouth as night sedation to patients admitted to hospital with respiratory failure. Fourteen patients had chronic obstructive bronchitis and six had acute severe asthma. One patient with asthma needed intravenous sedation with benzoctamine. No adverse effects were observed, and there was no significant change of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), or Pco2 in any patient after benzoctamine. Nevertheless, further clinical experience of the drug is required before its use can be safely recommended in respiratory failure.