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Hyperlactataemia in Phenformin-treated Diabetics

Br Med J 1972; 1 doi: (Published 22 January 1972) Cite this as: Br Med J 1972;1:205
  1. S. K. Varma,
  2. S. J. Heaney,
  3. W. G. Whyte,
  4. R. S. Walker


    Raised fasting blood lactate levels were observed in diabetic patients on phenformin in therapeutic dosage. After an intravenous glucose load this effect was exaggerated and the lactate/pyruvate ratio increased. Withdrawal of the drug led to normal blood lactate levels and a fall in the lactate/pyruvate ratio.