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Comparison of Two Oral Selective β2-Adrenergic Stimulant Drugs in Bronchial Asthma

Br Med J 1971; 1 doi: (Published 20 March 1971) Cite this as: Br Med J 1971;1:637
  1. J. S. Legge,
  2. J. Gaddie,
  3. K. N. V. Palmer


    The effect of two oral selective β2-stimulant drugs, salbutamol and terbutaline, on spirometry, arterial blood-gas tensions, pulse, and blood pressure was compared with placebo in a double-blind controlled trial in 12 asthmatic patients. Both drugs increased to forced vital capacity and the forced expiratory volume in 1 second equally for up to five hours, the maximal effect occurring at two to four hours. There was no significant change in arterial blood-gas tensions but both drugs increased pulse rate slightly. Tremor was the most common side effect. Terbutaline seems to be an effective alternative to salbutamol.