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Effect of Actinomycin D on Paget's Disease of Bone

Br Med J 1971; 1 doi: (Published 20 February 1971) Cite this as: Br Med J 1971;1:423
  1. James J. Fennelly,
  2. Joseph F. Groarke


    Four patients with active Paget's disease were treated with the RNA inhibitor actinomycin D. Three were clinically improved after treatment; the fourth had multiple collapsed vertebrae and showed no symptomatic improvement. Striking changes took place in urinary calcium and hydroxyproline, in serum alkaline phosphatase, and to a less extent in serum calcium and phosphate. These studies are continuing and are being compared with the effects of mithramycin.