Candida Endocarditis Treated with 5-FluorocytosineBr Med J 1971; 1 doi: https://doi.org/10.1136/bmj.1.5743.262 (Published 30 January 1971) Cite this as: Br Med J 1971;1:262
- C. O. Record,
- J. M. Skinner,
- P. Sleight,
- D. C. E. Speller
Three patients with endocarditis due to Candida species were treated with 5-fluorocytosine. One had endocarditis imposed on senile aortic sclerosis and survived and two had infections on prosthetic valves and died. In the latter two patients chemotherapy failed to eradicate the infection and was associated with marrow depression and possibly hepatic necrosis.