Papers And Originals

A Within-patient Comparison of Debrisoquine and Methyldopa in Hypertension

Br Med J 1971; 1 doi: (Published 09 January 1971) Cite this as: Br Med J 1971;1:75
  1. A. Heffernan,
  2. A. Carty,
  3. K. O'Malley,
  4. J. Bugler


    In a titrated dose cross-over trial of debrisoquine and methyldopa in 38 hypertensive patients neither drug was superior in lowering supine or standing diastolic pressure with a minimum of side effects. Methyldopa caused significantly greater reduction of supine (P<0·001) and standing (P<0·02) systolic pressure but caused intolerable side effects in two patients. Tiredness was the most characteristic and troublesome side effect with methyldopa and postural hypotension was prominent in patients while on debrisoquine.