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Preliminary Communications

Increased Pulmonary Arterial Pressures after Pentazocine in Myocardial Infarction

Br Med J 1970; 1 doi: (Published 28 March 1970) Cite this as: Br Med J 1970;1:795
  1. D. E. Jewitt,
  2. B. J. Maurer,
  3. P. J. B. Hubner


    In 15 patients with acute myocardial infarction intravenous pentazocine in a dose of either 30 or 60 mg. was followed by a significant increase in mean pulmonary arterial pressure. In the group receiving the 60-mg. dose this change was associated with a significant increase in systemic arterial pressure, total peripheral resistance, and left ventricular minute work. Because of these circulatory effects intravenous pentazocine in a dose of 60 mg. would seem to be unsuitable for the relief of pain in myocardial infarction.

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