Preliminary Communications

Urinary Hydroxyproline in the Elderly with Low Leucocyte Ascorbic Acid Levels

Br Med J 1970; 1 doi: (Published 21 March 1970) Cite this as: Br Med J 1970;1:732
  1. A. C. W. Windsor,
  2. C. B. Williams


    Fourteen elderly patients aged 58 to 91 with varying leucocyte ascorbic acid levels had urinary hydroxyproline/creatinine ratios measured before, during, and after treatment with ascorbic acid 1 g. daily for six days. The ratio increased during treatment in those patients whose initial ascorbic acid levels were below 15μg./108 white blood cells. It is suggested that collagen metabolism may be impaired in these patients, and that all such patients should receive ascorbic acid supplements.

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