Papers And Originals

Reduction in Incidence of Ampicillin Rash by Purification of Ampicillin

Br Med J 1970; 1 doi: (Published 21 February 1970) Cite this as: Br Med J 1970;1:469
  1. E. T. Knudsen,
  2. Janet M. Dewdney,
  3. J. A. P. Trafford


    Purification of ampicillin (Penbritin) with respect to protein impurities has been found significantly to reduce the incidence of rashes in treated patients. This may be related to findings in animals that injections of the isolated protein impurity can induce the formation of circulating IgG antibodies and skin-sensitizing antibodies.