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Immunoglobulin Levels in the Cerebrospinal Fluid

Br Med J 1970; 1 doi: (Published 14 February 1970) Cite this as: Br Med J 1970;1:396
  1. D. Riddoch,
  2. R. A. Thompson


    The immunoglobulins G, A, M, and D have been measured in the cerebrospinal fluid of 207 patients with neurological disease. Raised levels of IgG, expressed as a percentage of total cerebrospinal fluid (C.S.F.) protein, were found in 62% of 45 cases of multiple sclerosis compared with 14% of 160 cases with various other neurological disorders. Thus measurement of the IgG level is probably a useful confirmatory investigation in multiple sclerosis. IgA and IgM were found only in the C.S.F. of patients with a raised protein level, and IgD was not detected.