Papers And Originals

Double-Blind Controlled Clinical Trial of Clofazimine in Reactive Phases of Leprotamous Leprosy

Br Med J 1970; 1 doi: (Published 24 January 1970) Cite this as: Br Med J 1970;1:198
  1. A. B. A. Karat,
  2. Anbu Jeevaratnam,
  3. S. Karat,
  4. P. S. S. Rao


    A double-blind controlled trial in 24 lepromatous leprosy patients in reaction showed that clofazimine (Lamprene) controlled symptoms of erythema nodosum leprosum reaction in lepromatous leprosy better than prednisolone. Clofazimine also appeared to be significantly superior in preventing recurrence once the reaction had been controlled. There was a statistically significant rise in serum albumin among inpatients on clofazimine as compared with patients on prednisolone, but no difference in terms of neurological status, bacterial index, morphological index, and renal functions. Red/black hyperpigmentation was seen among practically all patients on clofazimine. No other side-effects or deleterious systemic effects were observed.


    • * Financed by J. R. Geigy, S.A., Basle, CH-4000 Basle 21, Switzerland.