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Personal use of permanent hair dye not associated with greater risk of most cancers or cancer death

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Personal use of permanent hair dye not associated with greater risk of most cancers or cancer death

But risk of some cancers, including basal cell carcinoma, some types of breast cancer and ovarian cancer is increased, study shows

Women who use permanent hair dye products to colour their hair at home do not experience greater risk of most cancers or greater cancer related mortality, finds a study published by The BMJ today.

While this should provide general reassurance to users of permanent hair dyes, the authors say they did find a slight increase in risk of ovarian cancer and some cancers of the breast and skin. Natural hair colour was also found to impact on the likelihood of some cancers.

Use of har dye is very popular, particularly among older age groups keen to cover up signs of grey. For example, it is estimated that it is used by 50-80% of women and 10% of men aged 40 and older in the United States and Europe.

The most aggressive hair dyes are the permanent types and these account for approximately 80% of hair dyes used in the US and Europe, and an even greater proportion in Asia. 

While the World Health Organization’s International Agency for Research on Cancer has classified occupational exposure to hair dyes as a probable carcinogen, there is no warning about personal use because existing evidence is inconclusive.

To gain a better understanding of the risk of cancer from use of personal hair dye, researchers analysed data on 117,200 women from the Nurses’ Health Study, based at Brigham and Women's Hospital, Boston, a large prospective cohort study, which includes assessments of hair dye exposure.

The women did not have cancer at the start of the study and were followed for 36 years.

The results showed no increased risk of most cancers or of cancer death in women who reported having ever used permanent hair dyes compared with those who had never used such dyes. 

Use of hair dye did not increase risk of cancers of the bladder, brain, colon, kidney, lung, blood and immune system, or most cancers of the skin (cutaneous squamous cell carcinoma and melanoma) or breast (estrogen receptor positive, progesterone receptor positive or hormone receptor positive).

Ever use of permanent dyes was associated with a slightly increased risk of the basal cell carcinoma of the skin, and this risk was higher in women with naturally light hair. 

An increased risk of three types of breast cancer - estrogen receptor negative, progesterone receptor negative, and hormone receptor negative - and ovarian cancer was also linked to use of permanent dyes, with risk rising according to the cumulative amount of dye women were exposed to. An increased risk of Hodgkin lymphoma was also seen with use of permanent hair dye but only for women with naturally dark hair.

“Possible explanations could be that shades of permanent hair dyes are associated with the concentration of ingredients, with darker colours having higher concentrations,” the authors say.

This is an observational study, so can’t establish cause. The authors also point to some limitations, including the lack of racial diversity of study participants, which mainly included white US women with European ancestry, and the possibility that other unmeasured factors, such as use of other products, may have affected the results.

What’s more, assessments of exposure to hair dye stopped relatively early in the follow-up period so some women may have started, stopped or changed their hair dye after this time, and some users of non-permanent hair dyes might have misclassified themselves as permanent hair dye users.

Nevertheless, the authors say their findings “offer some reassurance against concerns that personal use of permanent hair dyes might be associated with increased cancer risk or mortality.”

However, they add that the positive associations for some cancers with different hair colour types warrant further investigation.



Notes for editors
Research: Personal use of permanent hair dyes and cancer risk and mortality in US women: prospective cohort study
Journal: The BMJ

Funding: US Centers for Disease Control and Prevention and the National Institute for Occupational Safety and Health

Link to Academy of Medical Sciences press release labelling system:

Peer reviewed?
Yes Evidence type: Observational
Subjects: Female nurses

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