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Senior Clinical Research Fellow Hepatology (ST3+)

St George's University Hospitals NHS Foundation Trust
£37,068 to £57,570 a year pa pro rata
Closing date
28 Feb 2024

Job Details

An exciting opportunity to join the Gastroenterology and Hepatology department at St George's University Hospitals NHS Foundation Trust.This hepatology-based post would suite a dynamic individual looking to take an OOPE widen their experience and training in hepatology, but moreover dedicate a period of time to research with an aim to obtain a higher research degree (MD or PhD), apply for dedicated grant funding and share research findings amongst the hepatology community.

The research fellow will take up a 0.5 WTE clinical contract and be on the regional GI bleed rota. The clinical duties will include commitment to a gastroenterology and liver clinic, and an upper gastrointestinal endoscopy list. There will also be exposure to phase I-IIIclinical trials in St George's NIHR Clinical Research Facility as a sub-investigator. Appropriate training will be provided. The successful applicant will need also be independently proficient in therapeutic gastroscopy if they wish to participate in an out of hours upper GI bleeding rota. Support to achieve this could be discussed if not fully proficient.

Main duties of the job

The applicant is expected to develop a personal research project, under the supervision of Dr Arjuna Singanayagam and Professor Daniel Forton with expectation they will enrol for an MD or PhD. On commencing the post, the successful candidate will register their degree with the medical school. During the post there will be flexibility to attend the mandatory MD/PhD lecture programme. The department has an excellent MD/PhD supervision and completion record.

The out-of- hours GI bleed Rota exists across St George's, Croydon and Epsom/St Helier's Trusts which offers excellent experience paid by a separate on-call pathway.

Trainees are encouraged to apply for local and national research funding early in their research experience in order to structure and enhance financing of their project. In view of the part-time clinical activity, this offers an excellent on-going training opportunity within the out of programme experience. The timetable will include fixed commitments (an example outlined below for year 1) with remaining slots free for personal research activity.

About us

With over 9,000 dedicated staff caring for patients around the clock, we are the largest healthcare provider in southwest London.Our main site, St George's Hospital in Tooting - one of the country's principal teaching hospitals - is shared with St George's, University of London, which trains medical students and carries out advanced medical research. St George's Hospital also hosts the St George's, University of London and Kingston University Faculty of Health and Social Care Sciences, which is responsible for training a wide range of healthcare professionals from across the region.As well as acute hospital services, we provide a wide variety of specialist care and a full range of community services to patients of all ages following integration with Community Services Wandsworth in 2010.St George's University Hospitals NHS Foundation Trust serves a population of 1.3 million across southwest London. A large number of services, such as cardiothoracic medicine and surgery, neurosciences and renal transplantation, also cover significant populations from Surrey and Sussex, totalling around 3.5 million people.

Job description
Job responsibilities

  • To have responsibility for the Health, Safety and Welfare of self and others and to comply at all times with the requirement of the Health and Safety Regulations.
  • To ensure confidentiality at all times, only releasing confidential information obtained during the course of employment to those acting in an official capacity in accordance with the provisions of the Data Protection Act and its amendments.
  • To work in accordance with the Trusts Equal Opportunities policy to eliminate unlawful discrimination in relation to employment and service delivery.
  • To ensure skills are up-to-date and relevant to the role, to follow relevant Trust policies and professional codes and to maintain registration where this is a requirement of the role.
  • To be trained in and demonstrate fair employment practices, in line with trust policies.
  • To comply with St. Georges Healthcare No Smoking Policies.
  • To undertake such duties as may be required from time to time as are consistent with the responsibilities of the grade and the needs of the service.
  • This research project will be centred on investigating immunopathology and susceptibility to infection in patients with acute decompensated cirrhosis and acute-on-chronic liver failure (ACLF). It may include evaluating immune checkpoints on innate and adaptive immune cells, their role on immune cell function in the circulation and mechanisms of microbial translocation in contributing to septic and portal hypertensive complications in this cohort of patients. Depending on timelines and recruitment, the candidate may also be involved in a scientific sub-study of the PROMISE trial, a national multicentre study evaluating faecal microbiome transplantation vs. placebo in cirrhosis. In particular, the candidate would undertake laboratory work to determine the changes to monocyte phenotype and function with this intervention. Their laboratory work may involve collaboration and work at other London centres including Kings College London and Imperial College London as part of a wider collaborative research group.

    The candidate will be involved in patient screening, recruitment and biological sampling. They will be taught basic lab-based immunological techniques to generate novel data with no prior lab experience necessary. They will be supported in the lab by clinician scientist Dr Arjuna Singanayagam with support of the other members of the lab group. The aim would be to generate preliminary data sufficient to apply for external grant funding. If the candidate has specific research interests within the area of complications of cirrhosis or immune dysfunction in liver disease, the project can be negotiated. The successful candidate will be expected to register for an MD or PhD higher research degree with St. Georges University of London (SGUL) with supervision from Dr Singanayagam and Professor Forton.

Person Specification
Qualifications and Training

  • MBBS or equivalent
  • MRCP
  • Full GMC Registration


  • Experience of audit and research methodology


  • ST3+ gastro/hepatology training post or equivalent
  • Independent upper GI endoscopist
  • Experience on GI bleed rota


  • Computer skills including the ability to manage databases and image processing systems, which generate reliable research and clinical outcome data sets
  • Understand principles of audit
  • Understand principles and able to understand research results


  • Good medical knowledge and clinical skills
  • Clear, legible documentation


  • Some evidence of involvement in research or presentations at meetings/publications


  • Commitment to learning
  • Potential to cope with stressful situations and undertake responsibility
  • Excellent communication and interpersonal skills
  • Team worker and able to work independently using initiative





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