.highwire-markup ul{padding-left:40px;}.highwire-markup .contributors{text-align:left;}.highwire-markup div.contributors ol.contributor-list{font-weight:bold;list-style:none;margin:15px 0 0 0;padding:0;text-align:left;white-space:normal;}.highwire-markup div.contributors ol.contributor-list li{display:inline;line-height:1.1em;padding:0;margin:0;text-align:left;white-space:normal;}.highwire-markup div.contributors ol li a{border:0;font-weight:normal;text-decoration:none;vertical-align:.2em;}.highwire-markup .affiliation-list-reveal{margin-top:10px;}.highwire-markup .affiliation-list-reveal a.view-more{float:left;margin:0 5px;padding:0;text-align:center;width:0.9em;}.highwire-markup .affiliation-list-reveal a.view-more{border:0;display:block;font-size:1.5em;line-height:0.9em;padding:0 5px;}.highwire-markup div.contributors ol.affiliation-list{font-weight:normal;list-style:none;}.highwire-markup .hideaffil{left:-9999px;position:absolute;width:5000px;}.highwire-markup div.contributors ol.affiliation-list li{display:list-item;margin-left:5px;padding-left:0;}.highwire-markup div.contributors ol.affiliation-list li address{border:0;display:inline;font-style:italic;padding:0;margin:0;}.highwire-markup div.contributors ol.corresp-list{list-style:none;padding:0;margin:0;}.highwire-markup div.contributors ol.corresp-list li{margin-left:0;}.highwire-markup div.contributors li.corresp a{font-weight:normal;text-decoration:none;vertical-align:0em;}.highwire-markup .rev-xref-ref,.highwire-markup .rev-xref{font-family:"Lucida Sans Unicode",Arial,"Lucida Grande",Tahoma,Verdana,Helvetica,sans-serif;}.highwire-markup .corresp-list .corresp-label{font-size:0.85em;line-height:0;vertical-align:super;}.highwire-markup #content-block-markup ul.history-list{list-style-type:none;margin:5px 0;padding:0 0 0;}.highwire-markup .article div.section{border:0;clear:both;margin:0;padding:0;}.highwire-markup .article div.section h2{border:0;border-bottom:2px dotted #999;font-size:125%;margin:10px 0 10px 0;}.highwire-markup a.xref-bibr,.highwire-markup a.xref-fig,.highwire-markup a.xref-table{font-weight:bold;text-decoration:none;}.highwire-markup .article div.section h3,.highwire-markup .article div.section h4{display:inline;font-size:1.1em;font-weight:bold;padding:0;margin:0;margin-right:5px;text-transform:none;}.highwire-markup .article div.section h3{padding-bottom:10px;}.highwire-markup .article div.section h4{font-style:italic;}.highwire-markup ul.kwd-group{border-top:1px dotted #999;border-bottom:1px dotted #999;font-size:.833em;font-weight:bold;line-height:2;padding:.5em;margin:0;margin-bottom:1em;text-align:center;}.highwire-markup ul.kwd-group li.kwd{background-color:#d8d8d8;display:inline;padding:.5em;margin:0 .7em;line-height:2;white-space:normal;}.highwire-markup .article div.section{border:0;clear:both;margin:0;padding:0;}.highwire-markup .section .list-simple li{list-style:none;}.highwire-markup div.article .fig,.highwire-markup div.article .table{margin:1em 20px 1em 20px;clear:both;}.highwire-markup .fig-inline,.highwire-markup .table-inline{font-size:.85em;text-align:center;}.highwire-markup .fig-inline,.highwire-markup .table-inline{font-size:.85em;border:1px dotted #999;background-color:white;height:auto;padding:1em;margin:1em 10px;text-align:center;float:left;}.highwire-markup div.fig a.in-nw-vis{display:inline;}.highwire-markup .fig-caption,.highwire-markup .table-caption{background-color:#EEE;padding:.25em 1em;border-top:1px solid #CCC;border-left:1px solid #CCC;border-bottom:1px solid #AAA;border-right:1px solid #AAA;padding-top:1em;}.highwire-markup .fig-caption p,.highwire-markup .table-caption p,.highwire-markup .fig-caption span,.highwire-markup .table-caption span{line-height:1.4em;font-weight:bolder;}.highwire-markup .fig-label,.highwire-markup .table-label{font-weight:bold;}.highwire-markup .figure-callout{margin-bottom:0.6em;text-align:center;}.highwire-markup .figure-callout-links a{background:#F5F5F5;border:1px solid #DDD;-moz-border-radius:4px;-webkit-border-radius:4px;border-radius:4px;display:inline-block;font-size:0.85em;padding:0.5em;}.highwire-markup .figure-callout-links a:hover{background:#FCFCFC;}.highwire-markup .figure-callout-links span{display:inline-block;height:20px;line-height:20px;vertical-align:middle;}.highwire-markup .figure-callout-icon{height:20px;margin-right:5px;vertical-align:middle;width:20px;}#colorbox #cboxTitle{background:rgba(83,83,83,0.9);color:#FFF;}.highwire-markup div.caption-clear{clear:both;}.highwire-markup ul.copyright-statement{list-style-type:none;}.highwire-markup div.fn-group ul{list-style:none;margin:0;padding:0;padding-top:5px;}.highwire-markup div.bio{margin-top:1em;}.highwire-markup div.fn-group ul li{border-bottom:1px solid #C8C8C8;margin:0 auto;padding:.5em 0;text-align:left;width:95%;}.highwire-markup div.fn-group ul li p{margin-bottom:0;}.highwire-markup #content-block-markup div.fn-group ul li p{margin:.5em 0;padding:0;}.highwire-markup ol.ref-use-labels{list-style:none;margin-left:.5em;}.highwire-markup ol.cit-list{font-size:0.9em;margin-left:2.5em;padding-left:0;}.highwire-markup ol.cit-list li{display:list-item;padding:.3em 0;}.highwire-markup div.ref-list .rev-xref-ref,.highwire-markup div.ref-list .rev-xref-ref:link{border:0;text-decoration:none;}.highwire-markup div.ref-cit,.highwire-markup .ref-cit div,.highwire-markup .ref-cit cite,.highwire-markup .ref-cit ol,.highwire-markup .ref-cit li,.ui-cluetip-content div.ref-cit,.ui-cluetip-content .ref-cit div,.ui-cluetip-content .ref-cit cite,.ui-cluetip-content .ref-cit ol,.ui-cluetip-content .ref-cit li{display:inline;margin-left:0;margin-right:0;padding-left:0;padding-right:0;}.highwire-markup div.ref-cit .cit-metadata li,.ui-cluetip-content div.ref-cit .cit-metadata li{display:inline;}.highwire-markup ol.cit-list li,.ui-cluetip-content ol.cit-list li{display:list-item;padding:.3em 0;}.highwire-markup div.ref-cit cite,.ui-cluetip-content div.ref-cit cite{font-style:normal;}.highwire-markup div.ref-cit .cit-vol,.ui-cluetip-content div.ref-cit .cit-vol{font-weight:bolder;}.highwire-markup div.ref-cit div.cit-extra a,.ui-cluetip-content div.ref-cit div.cit-extra a{display:inline-block;font-size:88%;margin-left:0.75em;text-decoration:underline;vertical-align:middle;white-space:nowrap;}.highwire-markup div.ref-cit cite span.cit-source,.highwire-markup div.ref-cit cite abbr.cit-jnl-abbrev,.ui-cluetip-content div.ref-cit cite span.cit-source,.ui-cluetip-content div.ref-cit cite abbr.cit-jnl-abbrev{margin-right:.1em;font-style:italic;}.affiliation-list-reveal a.view-more{border:0;display:block;font-size:1.5em;line-height:0.9em;padding:0 5px;}.affiliation-list-reveal a.view-more{float:left;margin:0 5px;padding:0;text-align:center;width:0.9em;}.hw-article-citation div{font-size:0.9em;}.hw-article-citation div + div{margin-top:10px;}.hw-article-citation .citation-info{padding:0 5px 0 0;}.hw-article-citation .doi,.hw-article-citation .cit-date,.hw-article-citation .page-num{font-weight:bold;}.page-num .first-page + .last-page:before{content:" - ";}.orig-source{text-align:center;}.highwire-markup .issue-toc .toc-citation{margin-bottom:10px;}.highwire-markup .issue-toc ul.toc-section li{list-style-type:none;}.highwire-index-by-author-links ul li{padding:0;}.table-expansion{overflow:auto;width:100%;}.table-expansion table{font-family:monospace;}.table-expansion table thead{font-weight:bold;background-color:whitesmoke;}.table-expansion table th,.table-expansion table td{border:1px solid lightgrey;}.table-center{text-align:center;}sup,sub,.nlm-sup,.nlm-sub{font-size:0.75em;position:relative;bottom:0.5em;}sub,.nlm-sub{bottom:-0.5em;}.cit-ref-sprinkles{margin-left:10px;}ol.duplicate{display:none;}.highwire-markup .sc{font-size:0.85em;text-transform:uppercase;}