Screening PSA Results Should be Followed by Free PSA/PSA Ratio
The results confirm the expectation that as the cutoff level
increases from 3 to 5 ng/ml, the sensitivity decreases and specificity
increases. Assays for free PSA [fPSA] and a resultant calculation of a
fPSA/PSA ratio have been available since the early 1990s and are useful in
further discriminating, albeit not providing an absolute distinction,
between ca & BPH in individuals with PSA results between 4 to 10
ng/ml. The study populations would've been very suitable for confirming
the utility of the fPSA/PSA ratio. Numerous articles have been published
by Lilja, Stenman, Labrie, Catalona and others concerning the clinical
validity of this ratio.
Competing interests:
Former President/CEO of Medicorp Inc. of Montreal that developed assays for PSA and free PSA/PSA ratio.
Rapid Response:
Screening PSA Results Should be Followed by Free PSA/PSA Ratio
The results confirm the expectation that as the cutoff level
increases from 3 to 5 ng/ml, the sensitivity decreases and specificity
increases. Assays for free PSA [fPSA] and a resultant calculation of a
fPSA/PSA ratio have been available since the early 1990s and are useful in
further discriminating, albeit not providing an absolute distinction,
between ca & BPH in individuals with PSA results between 4 to 10
ng/ml. The study populations would've been very suitable for confirming
the utility of the fPSA/PSA ratio. Numerous articles have been published
by Lilja, Stenman, Labrie, Catalona and others concerning the clinical
validity of this ratio.
Competing interests:
Former President/CEO of Medicorp Inc. of Montreal that developed assays for PSA and free PSA/PSA ratio.
Competing interests: No competing interests