"In 1985 I suggested low DHEA could result in Alzheimer's disease.
While controversial, this hypothesis has since been supported. A case may
be made that low DHEA is connected to AD.
While I could not find research connecting quetiapine with DHEA,
quetiapine reduces prolactin which is a direct stimulator of DHEA and
quetiapine reduces cortisol which has been interpreted to indicate that
quetiapine shuts down the HPA axis.
I suggest the negative effects of quetiapine on individual with AD is
due to the shutdown of DHEA."
Rapid Response:
correction: this could be low DHEA...
"In 1985 I suggested low DHEA could result in Alzheimer's disease. While controversial, this hypothesis has since been supported. A case may be made that low DHEA is connected to AD.
While I could not find research connecting quetiapine with DHEA, quetiapine reduces prolactin which is a direct stimulator of DHEA and quetiapine reduces cortisol which has been interpreted to indicate that quetiapine shuts down the HPA axis.
I suggest the negative effects of quetiapine on individual with AD is due to the shutdown of DHEA."
Competing interests: None declared
Competing interests: No competing interests