|Reference Salicylic acid||Setting, design*||No of participants randomised (dropouts or withdrawals), age, type† and site of warts||Interventions||Outcomes||Notes||Quality|
|Varnavides et al 199745||Secondary care, blind||51 (9), adults, refractory, hands and feet||Interferon alfa (10 IU/ml weekly £12) v placebo||Cure in 12/23 (52%) v 12/19 (63%) at 24 weeks||Medium|
|Rosado-Cancino et al 198934||Secondary care, open||40 (0), children, refractory, anywhere||Dinitrochlorobenzene v placebo||Cure in 16/20 (80%) v 7/20 (35%) Duration of trial unclear||Low|
|Wilson 198348||Secondary care, open||60 (0), adults, ordinary, hands only||Dinitrochlorobenzene v cryotherapy v no treatment||Cure in 16/20 (80%), 10/20 (50%), and 8/20 (40%) at 4 months||Published as abstract only||Low|
|Stahl et al 197939||Secondary care, open||149 (29), adults and children, ordinary, hands and feet||Methylene blue and dimethyl sulphoxide v salicylic acid and creosote||Cure in 5/65 (8%) v 8/56 (15%) at 8 weeks||Low|
|Stender et al 199942||Secondary care, blind, intention to treat analysis, within patient||30 (2), adults, refractory, hands and feet||White (£3 and £1), red (£3), and blue (£3) light v cryotherapy (£4)||Cure in 73%, 71%, 42%, 28%, and 20% of warts at 4-6 weeks||Warts used as unit of analysis, results in % only, no placebo groups, and salicylic acid used in all groups||Medium|
|Stender et al 200043||Secondary care, blind, intention to treat analysis, within patient||45 (5), adults, refractory, hands and feet||20% aminolaevulinic acid and red light v placebo photodynamic therapy||Cure in 64/114 (56%) v 47/113 (42%) of warts at 18 weeks||High|
|Viein et al 197746||Secondary care, blind, left and right comparison study||56 (6), adults and children, refractory, hands and feet||Proflavine and dimethyl sulphoxide or neutral red and dimethyl sulphoxide v placebo photodynamic therapy (£8)||Cure in 10/27 (37%) proflavine v 10/23 (43%) neutral red at 8 weeks||Placebo half cured in all responders and no placebo response in all non-responders||Medium|
|Pulsed dye laser|
|Robson et al 200033||Secondary care, open||40 (5), adults, not stated, any site||Monthly pulsed dye laser (up to £4) v “conventional” treatment||Cure in 66% v 70% of warts Warts used as unit of analysis and||cure rates expressed as percentages only||Low|
All studies except left and right comparison studies and within patient design were parallel group randomised controlled trials. ?=not clear. Cryotherapy is with liquid nitrogen.
↵* Blinding refers to assessment of outcome only and not blinding of participants
† Refractory broadly defined as warts that did not respond to previous treatments
↵‡Callusolve contains a quarternary ammonium germicide.