Abstract
An open, randomized, multicenter study was conducted to compare the efficacy and safety of piperacillin/tazobactam and co-amoxiclav plus aminoglycoside in the treatment of hospitalized patients with severe community-acquired or nosocomial pneumonia. Of the 89 patients who entered the study, 84 (94%) were clinically evaluable. A favorable clinical response was observed in 90% of the piperacillin/ tazobactam group and in 84% of the co-amoxiclav/aminoglycoside group (not significant). The bacteriological efficacy was comparable in both groups (96% vs. 92%; not significant). There was only one fatal outcome in the piperacillin/tazobactam group compared to six in the co-amoxiclav/aminoglycoside group regimen (P=0.058). The adverse event rate was non-significantly lower in the piperacillin/ tazobactam group compared to the co-amoxiclav/aminoglycoside group (2% vs. 7%; P=0.32). Piperacillin/tazobactam is safe and highly efficacious in the treatment of serious pneumonia in hospitalized patients. It compares favorably with the combination of co-amoxiclav/aminoglycoside.
Publication types
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Clinical Trial
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Comparative Study
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Multicenter Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Amoxicillin-Potassium Clavulanate Combination / administration & dosage
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Amoxicillin-Potassium Clavulanate Combination / adverse effects
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Amoxicillin-Potassium Clavulanate Combination / therapeutic use*
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / therapeutic use*
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Community-Acquired Infections / drug therapy
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Cross Infection / drug therapy
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Drug Therapy, Combination / administration & dosage
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Drug Therapy, Combination / adverse effects
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Drug Therapy, Combination / therapeutic use*
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Female
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Gentamicins / administration & dosage
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Gentamicins / adverse effects
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Gentamicins / therapeutic use
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Humans
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Male
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Middle Aged
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Netilmicin / administration & dosage
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Netilmicin / adverse effects
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Netilmicin / therapeutic use
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Penicillanic Acid / administration & dosage
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Penicillanic Acid / adverse effects
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Penicillanic Acid / analogs & derivatives
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Penicillanic Acid / therapeutic use
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Piperacillin / administration & dosage
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Piperacillin / adverse effects
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Piperacillin / therapeutic use
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Piperacillin, Tazobactam Drug Combination
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Pneumonia, Bacterial / drug therapy*
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Pneumonia, Bacterial / microbiology
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Gentamicins
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Piperacillin, Tazobactam Drug Combination
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Netilmicin
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Amoxicillin-Potassium Clavulanate Combination
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Penicillanic Acid
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Piperacillin