Abstract
The efficacy and safety of a once-a-day antibiotic in the treatment of sinusitis was studied. Two randomly assigned groups were treated with either once-a-day cefixime, a third generation cephalosporin, or amoxicillin three times a day. One hundred and fourteen patients were evaluated with antral punctures, microbiologic evaluation, and radiographic studies. Cultures revealed 40% gram-negative organisms, 48% gram-positive, and 12% anaerobes. The most common bacteria were Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus and viridans group streptococci. Ninety-four percent of the cefixime group were cured compared with 96% of the amoxicillin group. Staphylococcus resistance was a problem in both groups, necessitating an occasional change to amoxicillin-clavulanate potassium in the amoxicillin group. Once-a-day antibiotics offer the potential for improved compliance in the treatment of sinusitis. Cefixime offers an additional benefit of covering beta-lactamase producing strains of bacteria which are increasing in incidence and resistant to many penicillins.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Administration, Oral
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Adolescent
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Adult
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Aged
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Amoxicillin / administration & dosage
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Amoxicillin / adverse effects
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Amoxicillin / therapeutic use*
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Amoxicillin-Potassium Clavulanate Combination
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / therapeutic use*
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Bacterial Infections / drug therapy*
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Capsules
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Cefixime
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Cefotaxime / administration & dosage
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Cefotaxime / adverse effects
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Cefotaxime / analogs & derivatives*
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Cefotaxime / therapeutic use
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Clavulanic Acids / administration & dosage
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Clavulanic Acids / therapeutic use
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Drug Administration Schedule
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Drug Therapy, Combination / administration & dosage
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Drug Therapy, Combination / therapeutic use
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Female
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Humans
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Male
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Middle Aged
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Prospective Studies
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Remission Induction
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Sinusitis / drug therapy
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Sinusitis / microbiology*
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Time Factors
Substances
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Anti-Bacterial Agents
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Capsules
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Clavulanic Acids
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Amoxicillin-Potassium Clavulanate Combination
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Amoxicillin
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Cefixime
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Cefotaxime