The decline of BCG immunity after neonatal vaccination: what about revaccination at one year?

Paediatr Perinat Epidemiol. 1993 Jul;7(3):334-8. doi: 10.1111/j.1365-3016.1993.tb00408.x.

Abstract

Two hundred and nineteen healthy newborns were vaccinated with the BCG vaccine, and their immunity was checked thereafter at 3, 6 and 12 months of age. We determined that 87% of tuberculin reactivity at 3 months declined to 61% at 12 months. Revaccination of nonreactive infants provided a 100% rate of reactivity. In the light of this information we propose a revision in the BCG vaccination programme in developing countries. We also found a close relationship between the tuberculin reactivity and scar formation after BCG vaccination, suggesting that a simple check of the left deltoid region for a BCG scar may give enough information about the child's immunity to tuberculosis.

MeSH terms

  • BCG Vaccine / administration & dosage
  • BCG Vaccine / immunology*
  • Humans
  • Immunization, Secondary*
  • Infant, Newborn
  • Time Factors
  • Vaccination

Substances

  • BCG Vaccine