Abstract
Effectiveness and side-effects of high- versus low-dose neuroleptic treatment of chronic psychosis have been assessed through a meta-analysis of 22 published randomized control trials comparing different neuroleptic doses. No incremental clinical improvement was found at doses above 375 mg equivalent of chlorpromazine, while a significant increase in adverse reactions was observed.
Publication types
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Comparative Study
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Meta-Analysis
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antipsychotic Agents / administration & dosage
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Antipsychotic Agents / adverse effects*
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Chlorpromazine / administration & dosage
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Chlorpromazine / adverse effects
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Chronic Disease
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Dose-Response Relationship, Drug
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Dyskinesia, Drug-Induced / etiology
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Humans
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Psychotic Disorders / drug therapy*
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Psychotic Disorders / psychology
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Randomized Controlled Trials as Topic
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Treatment Outcome
Substances
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Antipsychotic Agents
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Chlorpromazine