In December 2004, a new legislative framework for the random drug screening of drivers modeled on the successful random alcohol screening methodology came into force in Victoria, Australia. The new framework prohibits driving while methamphetamine (MA), 3,4-methylenedioxymethamphetamine (MDMA), and cannabis, delta-9-tetrahydrocannabinol (THC), are present at any level in a driver's specimen. This is enforced by police who have the legislative authority to randomly drug test drivers for the presence of MA, MDMA, and THC by oral fluid (saliva) sample screening at the roadside. This article outlines the new random drug testing legislative framework and the drug testing procedures currently in place in Victoria. This article also examines the data collected through the operation of the framework for the first two years since implementation in Victoria (December 2004-December 2006).