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Intranasal live-attenuated influenza vaccine (LAIV) is unlikely to cause egg-mediated allergic reactions in egg-allergic children

https://doi.org/10.1016/j.jaip.2014.11.017Get rights and content

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Acknowledgments

We are grateful to the children who participated in this study.

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    Citation Excerpt :

    It is possible that egg proteins in inactivated influenza vaccines play little or no role, and that hypersensitivity reflects a complex interaction of current and past environmental exposures in an immunologically vulnerable milieu. Severe allergic reactions to egg-based influenza vaccines in persons with egg allergy are uncommon [13–17]. In a randomized, prospective, double-blind, placebo controlled trial, Greenhawt et al. [18] evaluated the safety of TIV in children with a history of severe egg allergy, including anaphylaxis.

This report is independent research commissioned and funded by the Department of Health Policy Research Programme (National Vaccine Evaluation Consortium, 039/0031). The views expressed in this publication are those of the author(s) and not necessarily those of the Department of Health.

P. J. Turner is in receipt of a Clinician Scientist award funded by the UK Medical Research Council (Grant reference MR/K010468/1) and has received research support from the Department of Health through the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre awards to Imperial College London Healthcare NHS Trust.

Conflicts of interest: P. J. Turner has received research support from the Department of Health, NHS National Institute for Health Research, and UK Medical Research Council. M. Erlewyn-Lajeunesse has received support for attendance at scientific meetings from Allergy Therapeutics, ALK Albelo, MEDA Pharmaceuticals, and Thermo Fisher.

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