AJM Theme Issue: CardiologyClinical research studyTrend in Mortality after Stroke with Atrial Fibrillation
Section snippets
Study Period and Study Population
The study was conducted in Denmark from January 1, 1980 to December 31, 2002 (identification of incident stroke with previous or concomitant nonvalvular atrial fibrillation or flutter), and to September 10, 2004 (follow-up on vital status) in Denmark. During the study period the total population increased from about 5.1 million to 5.4 million, and the population of interest for the present study, namely subjects aged 40-89 years, increased from 2.1 to 2.5 million. The general health and
Results
During the study period from 1980 to 2002, we identified 24,470 subjects, aged 40-89 years, with an incident hospital diagnosis of stroke and a previous or concomitant diagnosis of nonvalvular atrial fibrillation or flutter; 11,554 were men and 12,916 were women. The age distribution and the proportion of men and women with a previous or a concomitant diagnosis of an endocrine or cardiovascular disease at baseline are shown in Table 1.
Discussion
We observed a marked advance in survival after stroke associated with nonvalvular atrial fibrillation or flutter. Several improvements have been introduced in medical treatment during the study period, such as oral anticoagulation, potent lipid lowering drugs, more intensive treatment of hypertension and heart failure, together with the establishment of facilities for thrombolysis, and stroke rehabilitation units. On the other hand, equipment for cerebral computed tomography or magnetic
Acknowledgments
This work was supported in part by the Clinical Institute, Aarhus University, and Western Danish Research Forum for Health Sciences.
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