Clinical OpinionIs vitamin E a safe prophylaxis for preeclampsia?
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Cited by (28)
Antenatal pomegranate juice rescues hypoxia-induced fetal growth restriction in pregnant mice while reducing placental cell stress and apoptosis
2018, PlacentaCitation Excerpt :Clinical trials with vitamin C, E, or both, were studied with the goal of reducing placental oxidative stress and improving outcomes in women at risk for pregnancy complications. These studies ultimately showed no benefit, and a debated small risk for harm [1–7]. Currently, low dose aspirin is endorsed as prophylaxis for preeclampsia and IUGR, yet only one-fourth of the at-risk patient population benefits [8].
Spontaneous decidualization in pseudopregnant rats with vitamin e deficiency
2016, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Vitamin E belongs to a group of fat-soluble compounds including tocopherols and tocotrienols and is an essential nutrient for reproduction [9]. Vitamin E deficiency (VED) during pregnancy causes miscarriage, pre-term birth, preeclampsia, or intrauterine growth restriction [10–12]. Vitamin E primarily acts as a lipid antioxidant and free-radical scavenger in the body, which protects lipids and lipoproteins against peroxidative damage [13].
Influence of mineral and vitamin supplements on pregnancy outcome
2012, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :In addition to its antioxidative properties vitamin E also has a variety of non-antioxidative pleiotropic effects on redox-regulated transcription [45], cell cycle [46], and cytokine signalling [47]. Vitamin E could also be a potential interferon-gamma (IFN-gamma) mimic, facilitating persistent proinflammatory reactions at the fetal–maternal interface [48]. The clinical significance of these actions is unclear.
Supplementation with vitamins C and e during pregnancy for the prevention of preeclampsia and other adverse maternal and perinatal outcomes: A systematic review and metaanalysis
2011, American Journal of Obstetrics and GynecologyCitation Excerpt :The explanation for why supplementation with vitamins C and E increases the risk of gestational hypertension and PROM is unknown. Banerjee et al27 have hypothesized that nonantioxidant effects of exogenous vitamin E could have detrimental effects on human pregnancy. Vitamin E therapy could prevent an immunologic switch from T-helper cell 1 to T-helper cell 2 that is vital for early-to-late transition in normal pregnancies.
Vitamin E Metabolism in the Fetus and Newborn Infant
2011, Fetal and Neonatal Physiology E-Book, Fourth EditionAn international trial of antioxidants in the prevention of preeclampsia (INTAPP)
2010, American Journal of Obstetrics and GynecologyCitation Excerpt :The dose of vitamin E that is required to suppress isoprostane levels (a marker of oxidative stress) has been documented in men,33 but not in pregnant women. Exogenous vitamin E may prevent an immunologic switch (T helper 1 to T helper 2) that is considered as crucial for early to late transition in normal pregnancy and it could be a potential interferon-γ mimic, facilitating proinflammatory responses at the maternal-fetal interface.34 It is possible that vitamin E exerts both potentially beneficial and detrimental effects.