General Obstetrics and Gynecology: ObstetricsPerinatal outcomes of in vitro fertilization twins: A systematic review and meta-analyses
Section snippets
Methods
The Meta-analysis of Observational Studies in Epidemiology consensus statement was followed.14
Results
A maximum of 8 case-control studies reported on a given outcome, with most outcomes reported on by fewer studies. The 3 studies that examined perinatal death had results that varied widely (OR, 1.40; 95% CI, 0.22-9.11; Figure 1; Note, Table VII includes key outcomes that include fixed and random effects summary statistics)
Seven studies that reported on PTB (defined as delivery at <37 weeks of gestation) resulted in a combined OR of 1.44 (95% CI, 0.94-2.22; Figure 2). The I2 value of 55.6%
Comment
IVF twins have an increase in PTB from 32 to 36 weeks of gestation compared with spontaneously conceived twins who were matched for maternal age (OR, 1.48; 95% CI, 1.05-2.10). The OR for PTB at <37 weeks of gestation in studies that also matched for parity was similar and approached statistical significance at a 5% level of significance (OR, 1.47; 95% CI, 1.01-2.44). The origin of the increase in PTB has yet to be determined. Possible causes include a factor inherent to the IVF technology, a
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