Elsevier

The Lancet

Volume 319, Issue 8268, 13 February 1982, Pages 351-355
The Lancet

DOUBLE-BLIND RANDOMISED CROSSOVER TRIAL OF MODERATE SODIUM RESTRICTION IN ESSENTIAL HYPERTENSION

https://doi.org/10.1016/S0140-6736(82)91389-7Get rights and content

Abstract

Nineteen unselected patients with mild to moderate essential hypertension, whose average supine blood pressure after two months' observation on no treatment was 156/98 mm Hg, were advised not to add salt to food and to avoid sodium-laden foods. After 2 weeks of sodium restriction patients were entered into an 8-week double-blind randomised crossover study of 'Slow Sodium' (Ciba) versus slow sodium placebo. The mean supine blood pressure was 7·1 mm Hg (6º·1%) lower in the fourth week of placebo than that in the fourth week of slow sodium (p<0·001). Urinary sodium excretion in the fourth week of slow sodium was 162±9 mmol/24 h and that in the fourth week of placebo was 86 mmol±9 mmol/24 h (p<0·001). There was no difference in potassium excretion. These results suggest that moderate sodium restriction achieved by not adding salt and avoiding sodium-laden foods should, if not already, become part of the management of essential hypertension.

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