Original researchNeonatal outcome in pregnancies from ovarian stimulation1
Section snippets
Materials and methods
The Swedish Medical Birth Register started in 1973 and contains information on nearly all births in Sweden.1 Since 1982, it is based on copies of the relevant medical documents from antenatal care clinics, delivery units, and the pediatric examination of the newborn. Since 1983, information on subfertility is included in the register, based on an interview made by the attending midwife at the first antenatal visit (usually weeks 10–12) and stated as number of years of involuntary childlessness.
Results
A total of 4029 women (1.3% of all delivered women) were identified as having a delivery after ovarian stimulation, resulting in 4307 infants born. There were 438,582 control women (no ovarian stimulation, no IVF).
The women undergoing ovarian stimulation were older and more often of parity 1 than the control women (Table 1). When the length of involuntary childlessness as a measurement of subfertility was compared between subfertile women who got ovarian stimulation and who did not, a maximum
Discussion
Early studies7, 8, 9, 10 found no increase in the total congenital malformation rate related to ovarian stimulation, but concern was raised over a possible association between the use of clomiphene citrate and neural tube defects, especially anencephaly.11 A review12 including also IVF pregnancies reached the conclusion that ovarian stimulation does not represent a risk factor for neural tube defects in the offspring. A later study13 found no association between ovarian stimulation and neural
References (18)
- et al.
Delivery and children born after in-vitro fertilisation in Sweden 1982–1995A retrospective cohort study
Lancet
(1999) - et al.
Ovulation induction and risk of neural tube defects
Lancet
(1994) - et al.
Clomiphene citrate and neural tube defectsA pooled analysis of controlled epidemiological studies and recommendations for future studies
Fertil Steril
(1995) - et al.
Assisted reproductive interventions and multiple birth
Obstet Gynecol
(2001) - et al.
A quality study of a medical birth registry
Scand J Soc Med
(1990) - et al.
Congenital malformations in infants born after in vitro fertilization. A population based study
Hum Reprod
(2000) EpC Report. Barn födda i Sverige efter provrörsbefruktning, 1982–1997 (Children born in Sweden after in vitro fertilization, 1982–1997)
(2000)Search for teratogenic risks with the aid of malformation registries
Teratology
(1987)Simple interval estimation of risk ratio
Am J Epidemiol
(1974)
Cited by (83)
The Regulative Nature of Mammalian Embryos
2018, Current Topics in Developmental BiologyCitation Excerpt :One of the most important factors facilitating this increased frequency is the artificial induction of ovulation. It has been shown that women undergoing ovarian stimulation deliver monozygotic twins nearly twice as likely as women who have not used this therapy (Källén, Olausson, & Nygren, 2002). The higher twinning frequency could be caused by a hardening of the zona induced by ovulatory hormones that increase the likelihood of accidental embryo bisection (Derom, Vlietinck, Derom, Van den Berghe, & Thiery, 1987; Edwards et al., 1986).
Association between ovarian stimulators with or without intrauterine insemination, and assisted reproductive technologies on multiple births
2015, American Journal of Obstetrics and GynecologyCitation Excerpt :This can be explained by the dominance of twin births (98%) among multiple birth groups in our study population, which is representative of the general population.1,7,10 As reported in previous studies,10,24 the OR of triplets was much higher than the OR of twins following ovarian stimulators used alone and this can be explained by the superovulation in an effort to increase cycle fecundity26,27 as well as hypersensitivity of women with PCOS to gonadotropins (one of the most used ovarian stimulators) leading to a multiple follicular development.1 This study has several strengths.
Health Outcomes of Children Conceived Through Assisted Reproductive Technology
2015, Handbook of Fertility: Nutrition, Diet, Lifestyle and Reproductive HealthLow-technology assisted reproduction and the risk of preterm birth in a hospital-based cohort
2015, Fertility and SterilityCitation Excerpt :Although this was a hospital-based cohort from a tertiary care center, the preterm birth rate after applying exclusions was similar to that of the overall Montreal population (38). Only few studies have examined the effect of low-technology assisted reproduction on the risk of preterm birth, with some heterogeneity in the methods and sources of data: two studies relied exclusively on countrywide registry-based data (27, 39); three studies used a combination of hospital-based data linked with various national databases (22, 35, 40); and one study used prospectively recruited primary data linked with outcome data from a national registry (41). Despite the differences in methods, our results are in general agreement: low-technology treatment is associated with an increased risk of preterm birth (22, 27, 35, 39, 40).
Do assisted-reproduction twin pregnancies require additional antenatal care?
2013, Reproductive BioMedicine Online
- 1
The study was made possible by data on in vitro fertilization, collected by the Committee on In Vitro Fertilization, National Board of Health and Welfare, Stockholm. Anders Ericson at the National Board of Health and Welfare participated in the initiation of the study but died during the summer of 2001 before its completion.