Alimentary TractThe seroprevalence of cagA-positive Helicobacter pylori strains in the spectrum of gastroesophageal reflux disease☆,☆☆
Section snippets
Patient population
Patients were enrolled at the Cleveland Clinic Foundation and the Nashville Department of Veterans Affairs Medical Center from September 1995 to January 1997. The study was approved by the Institutional Review Boards of both institutions. Informed consent was obtained in advance from all patients, and background data were collected on age, sex, race, diagnosis, reflux symptoms (including frequency and duration), and medications.
Before endoscopy, patients were questioned about frequency and
Prevalence of H. pylori
A total of 210 patients were evaluated, including 57 controls, 84 patients with GERD (48 nonerosive and 36 erosive), 48 patients with Barrett's esophagus (30 with conventional Barrett's esophagus and 18 with short-segment Barrett's esophagus), and 21 patients with Barrett's esophagus complicated by dysplasia or adenocarcinoma (12 patients with previous esophagectomy). The control population included patients with achalasia (18 patients), familial adenomatous polyposis (2 patients), chronic
Discussion
In this study, we showed that the prevalence of H. pylori infection in patients with GERD (erosive and nonerosive), Barrett's esophagus, and Barrett's esophagus complicated by dysplasia or adenocarcinoma is lower than in a control group of similar age, confirming the recent findings of Werdmuller and Loffeld.21 Although the magnitude of the difference was similar in the two studies, the results were statistically significant in the Werdmuller and Loffeld study,21 but not in this study, because
Acknowledgements
The authors thank Tom Lang for his helpful comments and suggestions in reviewing this manuscript.
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Address requests for reprints to: Gary W. Falk, M.D., Department of Gastroenterology, Desk S-40, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195. e-mail: [email protected]; fax: (216)444-9416.
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Supported by a research grant from Astra-Merck and from the Medical Research Service of the Department of Veterans Affairs.